Venebio’s principal scientists represent decades of large-scale, innovative research efforts that have led to developments in the fields of public health, harm reduction, clinical development, and cutting-edge informatics.
Scroll through the list of publications below to learn more about Venebio’s work across therapeutic areas and industries.
Zedler BK, Saunders WB, Joyce AR, Vick CC, Murrelle EL. Validation of a screening risk index for serious prescription opioid-induced respiratory depression or overdose in a US commercial health plan claims database. Pain Med. 2018;19(1);68-79. PMID:28340046
Nadpara P, Joyce A, Murrelle L, Carroll NC, Carroll NV, Barnard M, Zedler B. Risk factors for serious prescription opioid-induced respiratory depression or overdose: Comparison of commercially insured and Veterans Health Affairs populations. Pain Medicine. 2018;19(1):79-96, 2017. PMID:28419384
Jonas DE, Amick HR, Felter C, Weber RP, Arvanitis M, Stine A, Lux L, Middleton JC, Voisin C, Harris RP. Screening for obstructive sleep apnea in adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2017 Jan 24;317(4):415-433. PMID:28118460
Maes HH, Prom-Wormley E, Rhee SH, Hewitt JK, Young S, Corley R, McGue M, Iacono WG, Legrand L, Samek D, Murrelle EL, Eaves LJ, Silberg JL, Miles D, Schieken RM, Beunen GP, Thomis M, Kaprio J, Rose RJ, Dick DM, Boomsma DI, Bartels M, Vink JM, Lichtenstein P, White V, Neale MC. A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents. Nicotine Tobacco Research. 2017 Apr; 19(4): 401-409. PMID:27807125
Weiner S, Joyce A, Thomson H. The prevalence of nasal obstruction as a consideration in the treatment of opioid overdose. Forthcoming in Journal of Opioid Management, 2017.
Gartlehner G, Gaynes BN, Amick HR, Asher G, Morgan LC, Coker-Schwimmer E, Forneris C, Boland E, Lux LJ, Gaylord S, Bann C, Pierl CB, Lohr KN. Comparative Benefits and Harms of Antidepressants, Psychological, Complementary, and Exercise Treatments for Major Depression: An Evidence Report for a Clinical Practice Guideline From the American College of Physicians. Annals of Internal Medicine.2016 Mar 1;164(5):331-41. PMID:26857743
Kahwati LC, Felter C, Halpern M, Woodell CL, Boland E, Amick HR, Weber RP, Jonas DE. Primary care screening and treatment for latent tuberculosis infection in adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2016; 316(9): 970-983. PMID:27599332
Neely BA, Wilkins CE, Marlow LA, Malyarenko D, Kim Y, Ignatchenko A, Sasinowski H, Sasinowski M, Nyalwidhe JO, Kislinger T, Copland JA, Drake RR. Proteotranscriptomic analysis reveals stage specific changes in the molecular landscape of clear-cell renal cell carcinoma. PLoS ONE. 2016; 11(4): e0154074. PMID: 27128972
Thompson S, Varvel S, Sasinowski M, Burke JP. From value assessment to value co-creation: Informing clinical decision-making with medical claims data. Big Data. 2016 Sep;4(3):141-7. PMID: 27642718
Wurst KE, Zedler BK, Joyce AR, Sasinowski M, Murrelle EL. A Swedish population-based study of adverse birth outcomes among pregnant women treated with buprenorphine or methadone: Preliminary findings. Substance Abuse: Research and Treatment. 2016; 10: 89-97. PMID:27679504
Zedler BK, Mann AL, Kim MM, Amick HR, Joyce AR, Murrelle EL, Jones HE. Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus, and child. Addiction. 2016 Dec; 111(12): 2115-2128. PMID:27223595
Amick HR, Gartlehner G, Gaynes BN, Forneris C, Asher G, Morgan LC, Coker-Schwimmer E, Boland E, Lux LJ, Gaylord S, Bann C, Pierl CB, Lohr KN. Comparative benefits and harms of second-generation antidepressants and cognitive behavioral therapies in the initial treatment of major depressive disorder: systematic review and meta-analysis. British Medical Journal. 2015;351:h6019. Available here.
Gartlehner G, Gaynes BN, Amick HR, Asher G, Morgan LC, Coker-Schwimmer E, Forneris C, Boland E, Lux LJ, Gaylord S, Bann C, Pierl CB, Lohr KN. Nonpharmacological Versus Pharmacological Treatments for Adult Patients with Major Depressive Disorder. Comparative Effectiveness Review No. 161. (Prepared by the RTI-UNC Evidence-based Practice Center under Contract No. 290-2012-00008i) AHRQ Publication No. 15(16)-EHC031-EF. Rockville, MD: Agency for Healthcare Research and Quality. December 2015. Available here.
Wolin E, White J, Pottala JV, Sasinowski M, Dall T, Dayspring TD, McConnell JP, Hoefner DM, Warnick GR, Harris WS. Comparison between cardiometabolic risk biomarkers in a clinical laboratory patient cohort and the U.S. adult population. Journal of Clinical Lipidology, 2015 Nov-Dec;9(6):817-823. PMID:26687703
Zedler B, Xie L, Wang L, Joyce A, Vick C, Brigham J, Kariburyo F, Baser O, Murrelle L. Development of a risk index for serious prescription opioid-induced respiratory depression or overdose in Veterans’ Health Administration patients. Pain Medicine. 2015 Aug; 16(8): 1566-1579. PMID:26077738
Jonas DE, Amick HR, Feltner C, Wines C, Shanahan E, Rowe CJ, Garbutt JC. Association of genetic polymorphisms with variation in response to medications for alcohol dependence for adults: a systematic review and meta-analysis. Pharmacogenomics. 2014; 15(13): 1687-1700. PMID: 25410894
Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas KC, Wines R, Kim MM, Shanahan E, Gass CE, Garbutt JC. Pharmacotherapy for adults with alcohol-use disorders in outpatient settings: a systematic review and meta-analysis. JAMA. 2014; 311(18):1889. PMID:24825644
Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas KC, Wines R, Kim MM, Shanahan E, Gass CE, Garbutt JC. Pharmacotherapy for Adults with Alcohol-Use Disorders in Outpatient Settings. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 May. PMID:24945054
Jonas DE, Feltner C, Amick HR, Sheridan S, Zheng ZJ, Watford DJ, Carter JL, Rowe CJ, Harris R. Screening for Asymptomatic Carotid Artery Stenosis: A Systematic Review and Meta-Analysis for the U.S. Preventive Services Task Force. Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Jul. Report No.: 13-05178-EF-1. PMID:25057532
Jonas DE, Feltner C, Amick HR, Sheridan S, Zheng ZJ, Watford DJ, Carter JL, Rowe CJ, Harris R. Screening for asymptomatic carotid artery stenosis: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2014 Sep 2;161(5):336-46. PMID:25004169
Lavonas EJ, Severtson SG, Martinez EM, Bucher-Bartelson B, Le Lait MC, Green JL, Murrelle EL, Cicero T, Kurtz SP, Rosenblum A, Surratt HL, Dart RC. Abuse and diversion of buprenorphine sublingual tablets and film. Journal of Substance Abuse Treatment. Jul;47(1):27-34, 2014. PMID: 24680219
Sasinowski M. Beyond Personalized Medicine – Personalized Lifestyle. Anti-Aging Medical News, 2014.
Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, Sasinowska H, Zhu H, Drake R, Sasinowski M, Tun HW, Copland JA. Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration. Oncotarget, 2014. PMID: 24979721
Varvel SA, Voros S, Thiselton DL, Pottala JV, Dall T, Warnick GR, McConnell JP, Ghaedi L, Sasinowski M, Graham T. Comprehensive biomarker testing of glycemia, insulin resistance, and beta cell function has greater sensitivity to detect diabetes risk than fasting glucose and HbA1c. Journal of Cardiovascular Translational Research, 2014. PMID: 25070680
Varvel SA, Pottala JV, Thiselton DL, Caffrey R, Dall T, Sasinowski M, McConnell JP, Warnick GR, Graham T, Voros S. Serum alpha-hydroxybutyrate predicts elevated 1-hour glucose levels and early-phase beta-cell dysfunction during OGTT. BMJ Open Diabetes Research and Care, 2014. PMID: 25452875
Varvel SA, Dayspring TD, Edmonds Y, Thiselton DL, Ghaedi L, Voros S, McConnell JP, Sasinowski M, Dall T, Warnick GR. Discordance between apolipoprotein B and low-density lipoprotein particle number is associated with insulin resistance in clinical practice. Journal of Clinical Lipidology, 2014. PMID: 25911082
Zedler B, Xie L, Wang L, Joyce A, Vick C, Kariburyo F, Rajan P, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among Veterans Health Administration patients. Pain Medicine. 15:1911-29; 2014. PMID: 24931395
Hawn MT, Richman JS, Vick CC, Deierhoi RJ, Graham LA, Henderson WG, Itani KM. Timing of surgical antibiotic prophylaxis and the risk of surgical site infection. JAMA Surg. 2013 Jul 1;148(7):649-57. PMID: 23552769
Jonas DE, Wilkins TM, Bangdiwala S, Bann CM, Morgan LC, Thaler KJ, Amick HR, Gartlehner G. Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration Using Real-World Trial Data and Simulation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Feb. PMID:23469378
Lavonas EJ, Banner W, Bradt P, Bucher-Bartelson B, Brown KR, Rajan P, Murrelle L, Dart RC, Green JL. Root causes, clinical effects, and outcomes of unintentional exposures to buprenorphine by young children. Journal of Pediatrics. 163(5):1337-83. e1-3, 2013. PMID: 23993129
Watson L, Amick HR, Gaynes BN, Brownley KA, Thaker S, Viswanathan M, Jonas DE. Practice-Based Interventions Addressing Concomitant Depression and Chronic Medical Conditions in the Primary Care Setting: A Systematic Review and Meta-analysis. J Primary Care Community Health. 2013 Apr 1. PMID:23799670
Altom LK, Graham LA, Gray SH, Snyder CW, Vick CC, Hawn MT. Outcomes for incisional hernia repair in patients undergoing concomitant surgical procedures. Am Surg. 2012 Feb;78(2):243-9. PMID: 22369837
Altom LK, Deierhoi RJ, Grams J, Richman JS, Vick CC, Henderson WG, Itani KM, Hawn MT. Association between Surgical Care Improvement Program venous thromboembolism measures and postoperative events. Am J Surg. 2012 Nov;204(5):591-7 PMID: 22906249
Brown LE, Burton R, Hixon B, Kakade M, Bhagalia P, Vick C, Edwards A, Hawn MT. Factors influencing emergency department preference for access to healthcare. West J Emerg Med. 2012 Nov;13(5):410-5. PMID: 23359637
Cannon JA, Altom LK, Deierhoi RJ, Morris M, Richman JS, Vick CC, Itani KM, Hawn MT. Preoperative oral antibiotics reduce surgical site infection following elective colorectal resections. Dis Colon Rectum. 2012 Nov;55(11):1160-6 PMID: 23044677
Cheng J, Joyce A, Yates K, Aouizerat B, Sanyal AJ. Metabolomic profiling to identify predictors of response to vitamin E for non-alcoholic steatohepatitis (NASH). PLoS One. 7(9):e44106, 2012. PMID: 23028489
Jonas DE, Garbutt JC, Brown JM, Amick HR, Brownley KA, Council CL, Viera AJ, Wilkins TM, Schwartz CJ, Richmond ER, Yeatts J, Swinson Evans T, Wood SD, Harris RP. Screening, Behavioral Counseling, and Referral in Primary Care to Reduce Alcohol Misuse. Comparative Effectiveness Review No. 64. (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I.) AHRQ Publication No. 12-EHC055-EF. Rockville, MD: Agency for Healthcare Research and Quality. July 2012. Available here.
Jonas DE, Garbutt JC, Amick HR, Brown JM, Brownley KA, Council CL, et al. Behavioral counseling after screening for alcohol misuse in primary care: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Annals of Internal Medicine.2012;157(9):645-54. PMID:23007881
Watson L, Amick HR, Gaynes BN, Brownley KA, Thaker S, Viswanathan M, Jonas DE. Practice-Based Interventions Addressing Concomitant Depression and Chronic Medical Conditions in the Primary Care Setting. Comparative Effectiveness Review No. 75. (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I.) AHRQ Publication No. 12-EHC106-EF. Rockville, MD: Agency for Healthcare Research and Quality. August 2012. Available here.
Altom LK, Snyder CW, Gray SH, Graham LA, Vick CC, Hawn MT. Outcomes of emergent incisional hernia repair. Am Surg. 2011 Aug;77(8):971-6. PMID: 21944508
Applebee MK, Joyce AR, Conrad TM, Pettigrew DW, Palsson BØ. Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli. J Biol Chem. 286(26):23150-9, 2011. PMID: 21550976
Graham LA, Altom LK, Vick CC, Snyder CW, Deierhoi RJ, Hawn MT. Agreement between patient survey and medical chart: Pitfalls in measurement strategies for hernia recurrence. Surgery. 2011 Sep;150(3):371-8. PMID: 21783217
Griffiths A, Carrion R. Jr., Miller J, Sasinowska H, Sasinowski M, Patterson JL. An Electronic Inventory System Designed to Aid Compliance with the National Select Agents Registry Program. Applied Biosafety, 2011. Available here.
Hawn MT, Snyder CW, Graham LA, Gray SH, Finan KR, Vick CC. Hospital-level variability in incisional hernia repair technique affects patient outcomes. Surgery. 2011 Feb;149(2):185-91. PMID: 21238712
Hawn MT, Gray SH, Snyder CW, Graham LA, Finan KR, Vick CC. Predictors of mesh explantation after incisional hernia repair. Am J Surg. 2011 Jul;202(1):28-33. PMID: 21741517
Hawn MT, Vick CC, Richman J, Holman W, Deierhoi RJ, Graham LA, Henderson WG, Itani KM. Surgical site infection prevention: time to move beyond the surgical care improvement program. Ann Surg. 2011 Sep;254(3):494-9 PMID: 21817889
Jonas DE, Wines RCM, DelMonte M, Amick HR, Wilkins TM, Einerson BD, Schuler CL, Wynia BA, Shilliday BB. Drug Class Review: Controller Medications for Asthma: Final Update 1 Report. Portland (OR): Oregon Health & Science University; 2011 Apr. Available here.
Jonas DE, Van Scoyoc E, Gerrald K, Wines R, Amick H, Triplette M, Runge T. Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report. Portland (OR): Oregon Health & Science University; 2011 Feb. Available here.
Maher BS, Vladimirov VI, Latendresse SJ, Thiselton DL, McNamee R, Kang M, Bigdeli TB, Chen X, Riley BP, Hettema JM, Chilcoat H, Heidbreder C, Muglia P, Murrelle EL, Dick DM, Aliev F, Agrawal A, Edenberg HJ, Kramer J, Nurnberger J, Tischfield JA, Devlin B, Ferrell RE, Kirillova GP, Tarter RE, Kendler KS, Vanyukov MM. The AVPR1A Gene and Substance Use Disorders: Association, Replication, and Functional Evidence. Biol Psychiatry, 2011. PMID: 21514569
Snyder CW, Graham LA, Gray SH, Vick CC, Hawn MT. Effect of mesh type and position on subsequent abdominal operations after incisional hernia repair. J Am Coll Surg. 2011 Apr;212(4):496-502 PMID: 21463777
Snyder CW, Graham LA, Vick CC, Gray SH, Finan KR, Hawn MT. Patient satisfaction, chronic pain, and quality of life after elective incisional hernia repair: effects of recurrence and repair technique. Hernia. 2011 Apr;15(2):123-9. PMID: 21072550
Vick CC, Graham LA, Henderson WG, Houston TK, Hawn MT. Translating preoperative smoking cessation interventions into routine clinical care of veterans: provider beliefs. Transl Behav Med. 2011 Dec; 1(4): 604-608 PMID: 24073083
Zedler BK, Joyce A, Murrelle L, Kakad P, Harpe SE. A pharmacoepidemiologic analysis of the impact of calendar packaging on adherence to self-administered medications for long-term use. Clin Ther. 33(5): 581-97, 2011. PMID: 21665043
Zedler BK, Kakad P, Colilla S, Murrelle L, Shah NR. Does packaging with a calendar feature improve adherence to self-administered medication for long-term use? A systematic review. Clin Ther. 33(1): 62-73, 2011. PMID: 21397775
2010 and prior
Edmiston JS, Archer KJ, Scian MJ, Joyce AR, Zedler BK, Murrelle EL. Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. Biomarkers. 15(8):715-30, 2010. PMID: 20887155
Rana GS, York TP, Edmiston JS, Zedler BK, Pounds JG, Adkins JN, Varnum SM, Smith RD, Liu Z, Li G, Webb BT, Murrelle EL, Flora JW. Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD). Anal Bioanal Chem. 397(5):1809-19, 2010. PMID: 20442989
York TP, van den Oord EJCG, Langston TB, McKinney WJ, Webb BT, Murrelle EL, Zedler BK, Edmiston JS, Flora JW: High-resolution mass spectrometry proteomics for the identification of candidate plasma protein biomarkers for chronic obstructive pulmonary disease. Biomarkers, 15(4):367-77, 2010. PMID: 20429838
Meng H, Joyce AR, Adkins DE, Basu P, Jia Y, Li G, Sengupta TK, Zedler BK, Murrelle EL, van den Oord EJCG: A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling. BMC Bioinformatics 11:227, 2010. PMID: 20441598
McClay JL, Adkins DE, Isern NG, Connell T, Wooten JB, Zedler BK, Dasika MS, Webb BT, Webb-Robertson BJ, Pounds JG, Murrelle EL, Leppert M, van den Oord EJCG: 1H Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function, J Proteome Res. 9(6):3083-90, 2010. PMID: 20408573
Conrad TM, Frazier M, Joyce AR, Cho BK, Knight EM, Lewis NE, Landick R, Palsson BØ. RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media. Proc Natl Acad Sci U S A. 107(47):20500-5, 2010. PMID: 21057108
Joyce AR, Hawkins W, Fariss MW, Sengupta TK. Role of plasma membrane disruption in reference moist smokeless tobacco-induced cell death. Toxicol Lett. 198(2):191-9, 2010 PMID: 20600711
Mitchell C, Joyce AR, Piper JT, McKallip RJ, Fariss MW. Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death. Toxicol Lett. 195(1):23-30, 2010. PMID: 20206247
Murrelle L, Coggins CR, Gennings C, Carchman RA, Carter WH Jr, Davies BD, Krauss MR, Lee PN, Schleef RR, Zedler BK, Heidbreder C: Hypotheses and fundamental study design characteristics for evaluating potential reduced-risk tobacco products. Part I: Heuristic. Regulatory Toxicology & Pharmacology 57:1-10, 2010.
Murrelle L, Gennings C, Carchman RA, Carter WH, Lee PN, Zedler BK, Coggins CRE, Heidbreder C: Further considerations on the evaluation of potential reduced-risk tobacco products. Part II: Re-assessment of a heuristic using the CPS-II database. Regulatory Toxicology & Pharmacology 57:11-17, 2010.
Hawn MT, Snyder CW, Graham LA, Gray SH, Finan KR, Vick CC. Long-term follow-up of technical outcomes for incisional hernia repair. J Am Coll Surg. 2010 May;210(5):648-55, 655-7.
Amick HR, Carpenter WR “Community-Based Participatory Research (CBPR).” In Encyclopedia of Health Services Research. Ross M Mullner, (Ed.). SAGE Publications, Inc, Thousand Oaks, CA, 2009.
McCue C, Carchman RA, Zedler BK, McCue RJ. Family Smoking Prevention and Tobacco Control Act: Implications for the Law Enforcement Community. Food and Drug Law Institute Update Magazine Nov/Dec, 2009.
Argo JL, Vick CC, Graham LA, Itani KM, Bishop MJ, Hawn MT. Elective surgical case cancellation in the Veterans Health Administration system: identifying areas for improvement. Am J Surg. Nov 2009; 198(5):600-6.
Conrad TM, Joyce AR, Applebee MK, Barrett CL, Xie B, Gao Y, Palsson BO. Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short- term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations. Genome Biol. 10(10):R118, 2009.
Mejia R, Torres de Galvis Y, Heidbreder C, Murrelle L. The Construct of Impulsivity within the Context of Gender-Specific Adversity and Resilience during Adolescence: Recommendations for Future Work. In Impulsivity: Causes, Control and Disorders, GH Lassitor (Editor), Nova Science, 2009.
Coggins CRE, Murrelle EL, Heidbreder C: Light and intermittent cigarette smokers: A review (1989-2009), Psychopharmacology (Online ISSN: 1432-2072), 2009.
Gianchandani EP, Joyce AR, Palsson BO, Papin JA. Functional States of the genome-scale Escherichia coli transcriptional regulatory system. PLoS Computational Biology, 5(6):e1000403, 2009.
Joyce AR and Palsson BO. In silico Genome-scale Metabolic Models: The Constraint-based Approach and its Applications. in Systems Biology and Synthetic Biology. P. Fu, M. Latterich and S. Panke, Eds. John Wiley & Brothers, Inc.: Hoboken, NJ; 2009. pp. 193-233.
Zedler B, Frost-Pineda K, Oliveri D, Liang Q, Feng S, Roethig HJ. 12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers. Regul Tox Pharmacol. 52(2):111-117, 2008.
Cherrington A, Ayala GX, Amick H, Scarinci I, Allison J, Corbie-Smith G. Applying the community health worker model to diabetes management: using mixed methods to assess implementation and effectiveness. J Health Care Poor Underserved. 2008 Nov;19(4):1044-59.
Cherrington A, Ayala GX, Amick H, Allison J, Corbie-Smith G, Scarinci I. Implementing the community health worker model within diabetes management: challenges and lessons learned from programs across the United States. Diabetes Educ. 2008 Sep-Oct;34(5):824-33.
Eaves LJ, Prom EC, Hatemi PK, Murrelle EL. Family matters: Social influences exceed genetic effects on adolescent religious attitudes and practices. Social Forces 86(4):1621-1646, 2008.
Fanous AH, Neale MC, Webb BT, Straub RE, O’Neill FA, Walsh D, Riley BP, Kendler KS. Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high density families. Biological Psychiatry 64(2):121-127, 2008.
Frost-Pineda K, Zedler B, Oliveri D, Feng S, Liang Q, Roethig HJ. Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers. Regulatory Toxicology and Pharmacology 52(2):104-110, 2008.
Frost-Pineda K, Zedler B, Oliveri D, Liang Q, Feng S, Roethig HJ. 12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers. Regulatory Toxicology and Pharmacology 52(2):111-117, 2008.
Frost-Pineda K, Zedler BK, Liang Q, Roethig HJ. Environmental tobacco smoke (ETS) evaluation of a third-generation electrically heated cigarette smoking system (EHCSS). Regulatory Toxicology and Pharmacology 52(2):118-121, 2008.
Joyce AR and Palsson BO. Predicting gene essentiality using genome-scale in silico models. In: Osterman A and Gerdes S, editors. Gene essentiality at genome scale: protocols and bioinformatics. Totowa (NJ): Humana Press Inc.; 2008. pp. 433-457.
Meng H, Murrelle EL, Li G. Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles. BMC Bioinformatics 9:457-467, 2008.
Gray SH, Vick CC, Finan KR, Neumayer LA, Hawn MT. Umbilical Herniorrhapy in Cirrhosis: Improved Outcomes with Elective Repair. J Gastrointest Surg. Feb 13, 2008.
Hawn MT, Itani KM, Gray SH, Vick CC, Henderson W, Houston TK. Association of Timely Administration of Prophylactic Antibiotics for Major Surgical Procedures and Surgical Site Infection. J Am Coll Surg. May 2008; 206(5):814-9
Gray SH, Vick CC, Graham LA, Finan KR, Neumayer LA, Hawn MT. Variation in Mesh Placement for Ventral Hernia Repair: An Opportunity for Process Improvement?. Am J Surg. May 2008. Gray SH, Vick CC, Graham LA, Hawn MT. Enterotomy or unplanned bowel resection during elective hernia repair increases complications. Arch Surg. June 2008. 143(6) 582-6.
Roethig HR, Feng S, Liang Q, Liu J, Rees WA, Zedler BK. A 12-month, randomized, controlled study to evaluate exposure and cardiovascular risk factors in adult smokers switching from conventional cigarettes to a second-generation electrically heated cigarette smoking system. Journal of Clinical Pharmacology 48(5):580-591, 2008.
Tracy MB, Chen H, Weaver DM, Malyarenko DI, Sasinowski M, Cazares LH, Drake RR, Semmes JO, Tracy ER, Cooke WE. Precision Enhancement of MALDI-TOF-MS Using High Resolution Peak Detection and Label-Fed Alignment, Proteomics, 2008.
Sasinowski, M. So Much Data… So Little Time, (editorial), Drug Discovery, Issue 13, 2008.
Weiner BJ, Amick H, Lee SY. Conceptualization and measurement of organizational readiness for change: a review of the literature in health services research and other fields. Med Care Res Rev. 2008 Aug;65(4):379-436.* “2008 Best Article of the Year” by the MCRR Editorial Board
Feist AM, Henry CS, Reed JL, Krummenacker M, Joyce AR, Karp PD, Broadbelt LJ, Hatzimanikatis V, Palsson BO. A genome-scale reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Molecular Systems Biology 3:121, 2007.
Hua Q, Joyce AR, Palsson BO, Fong SS. Metabolic characterization of Escherichia coli strains adapted to growth on lactate. Applied and Environmental Microbiology 73(14):4639-4647, 2007.
Joyce AR and Palsson BO. Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach. In: Boshoff HI and Barry CE III, editors. Systems biological approaches in infectious diseases. Basel, Switzerland: Birkhauser Verlag; 2007. pp. 265, 267-309.
Kliewer W and Murrelle L. Risk and protective factors for adolescent substance use: Findings from a study of Central American youth. Journal of Adolescent Health 40:448-455, 2007.
Roethig HJ, Zedler BK, Kinser RD, Feng S, Nelson BL, Liang Q. Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system. Journal of Clinical Pharmacology 47(4):518-530, 2007.
Van den Oord EJC, McClay J, York T, Murrelle L, Robles JR. Genetics and diagnostic refinement. Behavior Genetics 37:535-545, 2007.
Chen H, Tracy ER, Cooke WE, Semmes OJ, Sasinowski M, Manos DM. Automated Peak Identification in a TOF-MS Spectrum, Medical Data Analysis, 2007.
Allen TE, Price ND, Joyce AR, Palsson BO. Long-range periodic patterns in microbial genomes indicate significant multi-scale chromosomal organization. PLoS Computational Biology 2(1):e2, 2006.
Gianchandani EP, Papin JA, Price ND, Joyce AR, Palsson BO. Matrix formalism to describe functional states of transcriptional regulatory systems. PLoS Comput Biol 2(8):e101 (2006).
Herring CD, Raghunathan A, Honisch C, Patel T, Applebee MK, Joyce AR, Albert TJ, Blattner FR, van den Boom D, Cantor CR, Palsson BO. Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale. Nature Genetics 38(12):1406-1412, 2006.
Hua Q, Joyce AR, Fong SS, Palsson BO. Metabolic analysis of adaptive evolution for in silico-designed lactate-producing strains. Biotechnology and Bioengineering 95(5):992-1002, 2006.
Joyce AR and Palsson BO. The model organism as a system: integrating ‘omics’ data sets. Nature Reviews Molecular Cell Biology 7(3):198-210, 2006.
Joyce AR, Easterling K, Holtzman SG, Kuhar MJ. Modeling the onset of drug dependence: a consideration of the requirement for protein synthesis. Journal of Theoretical Biology 240(4):531-537, 2006.
Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Journal of Bacteriology 188(23):8259-8271, 2006.
Kistler CE, Lewis CL, Amick HR, Bynum DL, Walter LC, Watson LC. Older adults’ beliefs about physician-estimated life expectancy: a cross-sectional survey. BMC Fam Pract. 2006 Feb 11;7:9.
Kliewer W, Murrelle L, Prom E, Ramirez M, Obando P, Sandi L, Warner E, Karenkaris M del C. Violence exposure and drug use in central american youth: family cohesion and parental monitoring as protective factors. Journal of Research on Adolescence 16:455-478, 2006.
Kuo PH, Neale MC, Riley BP, Webb BT, Sullivan PF, Vittum J, Patterson DG, Thiselton DL, van den Oord EJ, Walsh D, Kendler KS, Prescott CA. Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. Alcoholism: Clinical and Experimental Research 30(11):1807-1816, 2006.
Lewis CL, Kistler CE, Amick HR, Watson LC, Bynum DL, Walter LC, Pignone MP. Older adults’ attitudes about continuing cancer screening later in life: a pilot study interviewing residents of two continuing care communities. BMC Geriatr. 2006 Aug 3; 6(1):10.
Oh YK, Joyce AR, Palsson BO. Constraint-based genome-scale in silico models for systems biology. Asia-Pacific Biotech News 10:123-136, 2006.
Reed JL, Patel TR, Chen KH, Joyce AR, Applebee MK, Herring CD, Bui OT, Knight EM, Fong SS, Palsson BO. Systems approach to refining genome annotation. Proceedings of the National Academy of Sciences of the United States of America 103(46):17480-17484, 2006.
van den Oord EJCG, Rujescu D, Robles JR, Birrell C, Bukszár J, Murrelle L, Giegling I, Möller H-H-J, Middleton L, Muglia P. Factor structure and external validity of the PANSS revisited. Schizophrenia Research 82:213-223, 2006.
Zedler BK, Kinser R Oey J, Nelson B, Roethig HJ, Walk RA, Kuhl P, Rustemeier K, Schepers G, Von Holt K, Tricker AR. Biomarkers of exposure and potential harm in adult smokers of 3-7 mg tar yield (Federal Trade Commission) cigarettes and in adult non-smokers. Biomarkers 11(3):201-220, 2006.
Hawn MT, Gray SH, Vick CC, Itani KM, Bishop MJ, Ordin D, Houston TK. Timely Administration of Prophylactic Antibiotics for Major Surgical Procedures. J Am Coll Surg (2006) 203:803-11.
Zhang W, Matrisian LM, Holmbeck K, Vick CC, Rosenthal EL. Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo. BMC Cancer. 2006; 6:52.
Malyarenko DI, Cooke WE, Tracy ER, Drake RR, Sasinowski, Manos DM. Resampling and Deconvolution of Linear Time-of-Flight Records over 100 kDa Mass Range for Enhanced Profiling of Protein Modifications, Rapid Communications in Mass Spectrometry, 2006.
Malyarenko DI, Cooke WE, Tracy ER, Trosset MW, Semmes OJ, Sasinowski, M, Manos DM. Deconvolution Filters to Enhance Resolution of Dense Time-of-Flight Survey Spectra, Rapid Communications in Mass Spectrometry, 2006.
Vick CC, Finan KR, Kiefe C, Neumayer L, Hawn MT. Variation in Institutional Review processes for a multisite observational study. Am J Surg. Nov 2005; 190(5):805-809.
Finan KR, Vick CC, Kiefe CI, Neumayer L, Hawn MT. Predictors of wound infection in ventral hernia repair. Am J Surg. Nov 2005; 190(5):676-681.
Fong SS, Joyce AR, Palsson BO. Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states. Genome Research 15(10):1365-1372, 2005.
Fong SS, Joyce AR, Palsson BO. The econometrics of evolution. Nature Chemical Biology 1(4):191-192, 2005.
Malyarenko DI, Cooke WE, Adam B-L, Malik G, Chen H, Tracy ER, Trosset MW, Sasinowski M, Semmes OJ, Manos DM. Enhancement of Sensitivity and Resolution of SELDI TOF-MS Records for Serum Peptides Using Time Series Analysis Techniques, Journal of Clinical Chemistry, 2005.
Lin SM, Zhu L, Winter AQ, Sasinowski M, Kibbe WA. What is mzXML Good For?, Expert Review Proteomics, 2005.
Silberg JL, Febo San Miguel V, Murrelle EL, Prom E, Bates J, Canino G, Egger H, Eaves LJ. Genetic and environmental influences on temperament in the first year of life: The Puerto Rico Infant Twin Study (“PRINTS”). Twin Research 8:328-336, 2005.
Davanzo P, Kerwin L, Nikore V, Esparza C, Forness S, Murrelle L. Spanish translation and reliability testing of the child depression inventory. Child Psychiatry and Human Development 35:75-92, 2004.
Obando P, Kliewer W, Murrelle L, Svikis DS. The comorbidity of substance abuse and depressive symptoms in Costan Rican adolescents. Drug and Alcohol Dependence 76:37-44, 2004.
Malyarenko DI, Chen H, Wilkerson AL, Tracy ER, Cooke WE, Manos DM, Sasinowski M, Semmes OJ. GA+TOF SIMS Lineshape Analysis for Resolution Enhancement of MALDI MS Spectra of a Peptide Mixture, Applied Surface Science, 2004.
Watson LC, Lewis CL, Kistler CE, Amick HR, Boustani M. Can we trust depression screening instruments in healthy “old-old” adults? Int J Geriatr Psychiatry. 2004 Mar;19(3):278-85.
Kimmel HL and Joyce AR. Dopamine transporters: structure-activity relationships and regulation in neurons. In: Dopamine receptors and transporters, 2nd edition. Vernier P, Sidhi A, Laruelle M. editors. New York (NY): Marcel Dekker, Inc; 2003. pp. 467-500.
Kuhar MJ and Joyce AR. Is the onset of psychoactive drug effects compatible with a protein-synthesis mechanism? Neuropsychopharmacology 28 Suppl 1: S94-97, 2003.
Anderson LS, Beverly WT, Corey LA, Murrelle L. The Mid-Atlantic Twin Registry. Twin Research 5:499-501, 2002.
Stern SJ, Arnos L, Murrelle L, Oelrich K, Nance W, Pandya A. Attitudes of Deaf and Hard of Hearing Individuals toward Genetic Testing and Prenatal Diagnosis of Hearing Loss. Journal of Medical Genetics 39(6):449-453, 2002.
Strassberg M, Peters K, Marazita M, Ganger J, Watt-Morse M, Murrelle L, Tarter R, Vanyukov M. Pittsburgh Registry of Infant Multiplets (PRIM). Twin Research 5:499-501, 2002.
Sasinowski, M. Semantic Web: Biotechnology and Beyond (commissioned), Technology Trends, 2002.
Geisler SA, Olshan AF, Weissler MC, Cai J, Funkhouser WK, Smith J, Vick K. et al. p16 and p53 Protein expression as prognostic indicators of survival and disease recurrence from head and neck cancer. Clin Cancer Res. Nov 2002; 8(11):3445-3453.
Kimmel HL, Joyce AR, Carroll FI, Kuhar MJ. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of Pharmacology and Experimental Therapeutics 298(1): 129-140, 2001.
Kliewer W, Murrelle L, Mejia R, Torres de Y, Angold A. Exposure to violence against a family member and internalizing symptoms in Colombian adolescents: the protective effects of family support. Journal of Consulting and Clinical Psychology 69(6):971-982, 2001.
Kuhar MJ and Joyce AR. Slow onset of CNS drugs: can changes in protein concentration account for the delay? Trends in Pharmacological Sciences 22(9):450-456, 2001.
Kuhar MJ, Joyce A, Dominguez G. Genes in drug abuse. Drug and Alcohol Dependence 62(3):157-162 2001.
Murrelle L and McCarthy C. What’s so important about conducting research involving third parties. Journal of Continuing Education in the Health Professions 21(4):198-202, 2001.
Vrana PB, Matteson PG, Schmidt JV, Ingram RS, Joyce A, Prince KL, Dewey MJ, Tilghman SM. Genomic imprinting of a placental lactogen gene in Peromyscus. Development Genes and Evolution 211(11):523-532, 2001.
Maya J, Torres de G. Y, Murrelle L, Mejía R, Calderón G. Consumption of psychoactive substances and other factors associated with juvenile delinquency. Monograph of the Institute for Health Sciences (CES), Medellín, Colombia, 2000.
D’Onofrio B, Eaves L, Murrelle L, Maes H, Spilka B. Understanding biological and social influences on religious attitudes and behaviors: A behavior-genetic perspective. Journal of Personality 67:953-984, 1999.
D’Onofrio BM, Murrelle L, Eaves LJ, McCullough ME, Landis JL, Maes HH: Adolescent religiousness and its influence on alcohol and drug use: Preliminary findings from the Mid-Atlantic Twin Study. Twin Research 60:293-305, 1999.
Maes HH, Woodard CE, Murrelle L, Meyer JM, Silberg JL, Hewitt JK, Rutter M, Simonoff E, Pickles A, Neale MC, Eaves LJ. Tobacco, alcohol and drug use in 8-16 year old twins: The Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Journal of Studies on Alcohol 60:293-305, 1999.
Pineda DA, Henao GC, Puerta IC, Mejia SE, Gomez LF, Miranda ML, Rosselli M, Ardila A, Restrepo MA, Murrelle L. The use of brief questionnaire in the diagnosis of attention deficit. Reviews in Neurology 28(4):365-372, 1999.
Silberg JL, Pickles A, Rutter ML, Siminoff E, Hewitt JK, Maes HK, Carbonneau R, Murrelle L, Foley D, Eaves L. The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry 56:225-232, 1999.
Tomkins JP, Miller–Smith H, Sasinowski M, Sasinowski H, Choi S, Verce M, Freedman D, Dean RA, Wing RA. Physical Map and Gene Survey of the Ochrobactrum anthropi Using Bacterial Artificial Chromosome Contigs. Microbial and Comparative Genomics, 1999.
Zhu H, Blackmon B, Sasinowski M, and Dean R. Physical Map and Organization of Chromosome 7 in the Rice Blast Fungus, Magnaporthe grisea. Genome Research, 1999.
Sasinowska H and Sasinowski M. An Algorithm for the Assembly of Robust Physical Maps Based on a Combination of Multi-level Hybridization Data and Fingerprinting Data. (commissioned) Computers and Chemistry, 1999.
Breembroek GRM, van Straalen A, Witkamp GJ, van Rosmalen GM, Moss HB, Bonicatto S, Kirisci L, Giradelli AM, Murrelle L. Substance abuse and associated psychosocial problems among argentine adolescents in Buenos Aires Province: Sex heterogeneity and familial transmission. Drug and Alcohol Dependence 52:221-230, 1998.
Majumder PP, Moss HB, Murrelle L. Familial and non-familial factors in the prediction of disruptive behaviors in boys at risk for substance abuse. Journal of Child Psychology and Psychiatry 39:203-213, 1998.
Brigham J, Moss HB, Murrelle L, Herning RI, Tarter RE. Event-related potential negative shift in sons of polysubstance- and alcohol-use disorder fathers. Psychiatry Research 73:133-146, 1997.
Sasinowski, M. and Boozer, A.H., A f Monte Carlo Method to Calculate Plasma Parameters. Physics of Plasmas, 1997.
Sasinowski, M. and Boozer, A.H., A f Monte Carlo Method to Calculate Plasma Currents. Physics of Plasmas, 1995.
Overstreet DH, Kampov-Polevoy A, Rezvani AH, Murrelle L, Halikas JA, Janowsky DS. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcoholism: Clinical and Experimental Research 17:1-4, 1993.
Murrelle L, Ainsworth BE, Doody JM, Holliman SC, Bulger D. Computerized mental health screening for college students: Correlation with standard pencil and paper questionnaires. American Journal of Health Promotion 7:90-92, 1992.
Montoya ID, Murrelle L. Prevalence of clinical depression as measured by the Zung Self-Rating Depression Scale (SDS) in physicians during post-graduate medical training in Medellín, Colombia. Medicina Universidad Pontificia Bolivariana 8(1):59-72, 1989 [Spanish].
Murrelle L, Escalona R, Florenzano R. Epidemiologic report on psychoactive substance use in 16 countries of Latin American and the Caribbean. Bulletin of the Panamerican Health Organization 107(6):595-644, 1989.
Murrelle L, Torres de Galvis Y, Orejuela E. Diagnostic tests as a clinical aid and for use in mental health screening. In: Application, Scoring and Interpretation Manual for the Second National Workshop on the Use of Clinical-Research Instruments in Addiction, Mental Hospital of Antioquia, Medellín, Colombia; pp. 110-115, 1988.
Murrelle L. Alcoholism research: A new approach to an old problem. Source 2(1):23-26, 1989.
Murrelle L. Alcoholism: Genetic and biochemical aspects. Revista del Hospital Mental de Antioquia 12(3): 13-18, 1986 [Spanish].
Murrelle L. PC Statistician: A “friendly” biostatistics package for the microcomputer. In: Application, scoring and interpretation manual for the second national workshop on the use of clinical-research instruments in addiction. Mental Hospital of Antioquia: Medellín, Colombia; 1988. pp. 127-131.
Torres de Galvis Y, Murrelle L. National household survey on alcoholism and the consumption of dependence-producing substances, Colombia – 1987. University of Antioquia Press: Medellín, Colombia; 1988.
Torres de Galvis Y, Murrelle L. The consumption of dependence-producing substances in Colombia. Bulletin of the Panamerican Health Organization 107(6):485-494, 1989.