Venebio’s principal scientists represent decades of large-scale, innovative research efforts that have led to developments in the fields of public health, harm reduction, clinical development, and cutting-edge informatics.

Scroll through the list of publications below to learn more about Venebio’s work across therapeutic areas and industries.


Lintzeris N, Mankabady B, Rojas-Fernandez C, Amick H. Strategies for transfer from methadone to buprenorphine for treatment of opioid use disorders and associated outcomes: A Systematic Review. Journal of Addiction Medicine. 2021 Apr 26. Available here.

Teames R, Joyce A, Scranton R, Vick C, Nagaraj N. Characterization of Device-Related Malfunction, Injury, and Death Associated with Using Elastomeric Pumps for Delivery of Local Anesthetics in the US Food and Drug Administration MAUDE Database. Drug, Healthcare and Patient Safety. 2020;12:293. Available here.

Frias-De-Diego A, Posey R, Pecoraro BM, Fernandes Carnevale R, Beaty A, Crisci E. A Century of Swine Influenza: Is It Really Just about the Pigs?. Veterinary Sciences. 2020 Dec;7(4):189. Available here.

Hopewell E, Harrison SH, Posey R, Duke EG, Troan B, Harrison T. Analysis of Published Amphibian Neoplasia Case Reports. Journal of Herpetological Medicine and Surgery. 2020 Sep;30(3):148-55. Available here.

Metcalfe L, Murrelle EL, Vu L, Joyce AJ, Preston VA, Maryon T, McDanald C, Yoo P. Independent Validation in a Large Privately Insured Population of the Risk Index for Serious Prescription Opioid–Induced Respiratory Depression or Overdose, Pain Medicine, 2020. E-pub ahead of print. Available here.


Patti M, Renfro CP, Posey R, Wu G, Turner K, Ferreri SP. Systematic review of medication synchronization in community pharmacy practice. Research in Social and Administrative Pharmacy. 2019 Nov 1;15(11):1281-8. Available here.

Mountcastle SB, Joyce AR, Sasinowski M, Costello N, Doshi S, Zedler BK. Validation of an administrative claims coding algorithm for serious opioid overdose: A medical chart review. Pharmacoepidemiology and drug safety. 2019 Oct 1. Available here.

Chilcoat HD, Amick HR, Sherwood MR, Dunn KE. Buprenorphine in the United States: Motives for abuse, misuse, and diversion. Journal of Substance Abuse Treatment. 2019 Jul 12. Available here.

Mays JW, Carey BP, Posey R, Gueiros LA, France K, Setterfield J, Woo SB, Sollecito TP, Culton D, Payne AS, Greenberg MS. World Workshop of Oral Medicine VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus. Oral Diseases. 2019 Jun;25:111-21. Available here.

Gueiros LA, France K, Posey R, Mays JW, Carey B, Sollecito TP, Setterfield J, Woo SB, Culton D, Payne AS, Lodi G. World Workshop on Oral Medicine VII: Immunobiologics for salivary gland disease in Sjögren’s syndrome: A systematic review. Oral Diseases. 2019 Jun;25:102-10. Available here.


Zedler BK, Saunders WB, Joyce AR, Vick CC, Murrelle EL.  Validation of a screening risk index for serious prescription opioid-induced respiratory depression or overdose in a US commercial health plan claims database.  Pain Med. 2018;19(1);68-79. Available here.

Rackers HS, Thomas S, Williamson K, Posey R, Kimmel MC. Emerging literature in the microbiota-brain axis and perinatal mood and anxiety disorders. Psychoneuroendocrinology. 2018 Sep 1;95:86-96. Available here.

Nadpara P, Joyce AMurrelle L, Carroll NC, Carroll NV, Barnard M, Zedler B. Risk factors for serious prescription opioid-induced respiratory depression or overdose:  Comparison of commercially insured and Veterans Health Affairs populations. Pain Medicine2018;19(1):79-96, 2017. Available here.


Jonas DE, Amick HR, Felter C, Weber RP, Arvanitis M, Stine A, Lux L, Middleton JC, Voisin C, Harris RP. Screening for obstructive sleep apnea in adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2017 Jan 24;317(4):415-433. Available here.

Lee C, Whang YM, Campbell P, Mulcrone PL, Elefteriou F, Cho SW, Park SI. Dual targeting c-met and VEGFR2 in osteoblasts suppresses growth and osteolysis of prostate cancer bone metastasis. Cancer Letters. 2018 Feb 1;414:205-13. Available here.

Maes HH, Prom-Wormley E, Rhee SH, Hewitt JK, Young S, Corley R, McGue M, Iacono WG, Legrand L, Samek D, Murrelle EL, Eaves LJ, Silberg JL, Miles D, Schieken RM, Beunen GP, Thomis M, Kaprio J, Rose RJ, Dick DM, Boomsma DI, Bartels M, Vink JM, Lichtenstein P, White V, Neale MC. A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents. Nicotine Tobacco Research. 2017 Apr; 19(4): 401-409. Available here.

Marking S, Krosnowski K, Ogura T, Lin W. Dichotomous distribution of putative cholinergic interneurons in mouse accessory olfactory bulb. Frontiers in Neuroanatomy. 2017 Feb 27;11:10. Available here.

Mulcrone PL, Campbell JP, Clément‐Demange L, Anbinder AL, Merkel AR, Brekken RA, Sterling JA, Elefteriou F. Skeletal colonization by breast cancer cells is stimulated by an osteoblast and β2AR‐dependent neo‐angiogenic switch. Journal of Bone and Mineral Research. 2017 Jul;32(7):1442-54. Available here.

Weiner S, Joyce A, Thomson H. The prevalence of nasal obstruction as a consideration in the treatment of opioid overdose. Forthcoming in Journal of Opioid Management, 2017. Available here.


Gartlehner G, Gaynes BN, Amick HR, Asher G, Morgan LC, Coker-Schwimmer E, Forneris C, Boland E, Lux LJ, Gaylord S, Bann C, Pierl CB, Lohr KN. Comparative Benefits and Harms of Antidepressants, Psychological, Complementary, and Exercise Treatments for Major Depression: An Evidence Report for a Clinical Practice Guideline From the American College of Physicians. Annals of Internal Medicine.2016 Mar 1;164(5):331-41. Available here.

Kahwati LC, Felter C, Halpern M, Woodell CL, Boland E, Amick HR, Weber RP, Jonas DE. Primary care screening and treatment for latent tuberculosis infection in adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA2016; 316(9): 970-983. Available here.

Ludwik KA, Campbell JP, Li M, Li Y, Sandusky ZM, Pasic L, Sowder ME, Brenin DR, Pietenpol JA, O’Doherty GA, Lannigan DA. Development of a RSK inhibitor as a novel therapy for triple-negative breast cancer. Molecular Cancer Therapeutics. 2016 Nov 1;15(11):2598-608. Available here.

Wurst KE, Zedler BK, Joyce AR, Sasinowski M, Murrelle EL. A Swedish population-based study of adverse birth outcomes among pregnant women treated with buprenorphine or methadone: Preliminary findings. Substance Abuse: Research and Treatment. 2016; 10: 89-97. Available here.

Zedler BK, Mann AL, Kim MM, Amick HR, Joyce AR, Murrelle EL, Jones HEBuprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus, and child. Addiction. 2016 Dec; 111(12): 2115-2128. Available here.


Amick HR, Gartlehner G, Gaynes BN, Forneris C, Asher G, Morgan LC, Coker-Schwimmer E, Boland E, Lux LJ, Gaylord S, Bann C, Pierl CB, Lohr KN. Comparative benefits and harms of second-generation antidepressants and cognitive behavioral therapies in the initial treatment of major depressive disorder: systematic review and meta-analysis. British Medical Journal2015;351:h6019. Available here.

Campbell JP, Mulcrone P, Masood SK, Karolak M, Merkel A, Hebron K, Zijlstra A, Sterling J, Elefteriou F. TRIzol and Alu qPCR-based quantification of metastatic seeding within the skeleton. Nature Scientific Reports. 2015 Aug 14;5(1):1-8. Available here.

Gartlehner G, Gaynes BN, Amick HR, Asher G, Morgan LC, Coker-Schwimmer E, Forneris C, Boland E, Lux LJ, Gaylord S, Bann C, Pierl CB, Lohr KN. Nonpharmacological Versus Pharmacological Treatments for Adult Patients with Major Depressive Disorder. Comparative Effectiveness Review No. 161. (Prepared by the RTI-UNC Evidence-based Practice Center under Contract No. 290-2012-00008i) AHRQ Publication No. 15(16)-EHC031-EF. Rockville, MD: Agency for Healthcare Research and Quality. December 2015. Available here.

Richards DL, Campbell C, Adams A, Fantahun S, Layne K. Evaluation of a community health worker training program on hypertension and diabetes in Limpopo Province South Africa: Retention of knowledge and application within the community one year later. Annals of Global Health. 2015 Mar 12;81(1). Available here.

Richards DL, Layne K, Fantahun S, Adams A, Campbell C. The ubuntu spirit of motivational interviewing: A pilot curriculum for community health workers in Limpopo, SA. Annals of Global Health. 2015 Mar 12;81(1). Available here.

Zedler B, Xie L, Wang L, Joyce A, Vick C, Brigham J, Kariburyo F, Baser O, Murrelle L. Development of a risk index for serious prescription opioid-induced respiratory depression or overdose in Veterans’ Health Administration patients. Pain Medicine. 2015 Aug; 16(8): 1566-1579. Available here.

Viswanathan M, Kahwati LC, Golin CE, Blalock SJ, Coker-Schwimmer E, Posey R, Lohr KN. Medication therapy management interventions in outpatient settings: a systematic review and meta-analysis. JAMA Internal Medicine. 2015 Jan 1;175(1):76-87. Available here.


Elefteriou F, Campbell P, Ma Y. Control of bone remodeling by the peripheral sympathetic nervous system. Calcified Tissue International. 2014 Jan;94(1):140-51. Available here.

Jonas DE, Amick HR, Feltner C, Wines C, Shanahan E, Rowe CJ, Garbutt JC. Association of genetic polymorphisms with variation in response to medications for alcohol dependence for adults: a systematic review and meta-analysis. Pharmacogenomics. 2014; 15(13): 1687-1700. PMID: Available here.

Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas KC, Wines R, Kim MM, Shanahan E, Gass CE, Garbutt JC. Pharmacotherapy for adults with alcohol-use disorders in outpatient settings: a systematic review and meta-analysis. JAMA2014; 311(18):1889. Available here.

Jonas DE, Feltner C, Amick HR, Sheridan S, Zheng ZJ, Watford DJ, Carter JL, Rowe CJ, Harris R. Screening for asymptomatic carotid artery stenosis: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Annals of Intern Medicine. 2014 Sep 2;161(5):336-46. Available here.

Lavonas EJ, Severtson SG, Martinez EM, Bucher-Bartelson B, Le Lait MC, Green JL, Murrelle EL, Cicero T, Kurtz SP, Rosenblum A, Surratt HL, Dart RC. Abuse and diversion of buprenorphine sublingual tablets and film. Journal of Substance Abuse Treatment. Jul;47(1):27-34, 2014. Available here.

Lee C, Campbell P, Whang YM, Young JD, Elefteriou F, Park SI. Targeting c-Met and VEGFR2 in the stromal compartment of prostate cancer bone metastasis. Proceedings of the 105th Ann Meeting of the AACR. Cancer Research. 2014 Oct 1;74. Available here.

Zedler B, Xie L, Wang L, Joyce A, Vick C, Kariburyo F, Rajan P, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among Veterans Health Administration patients. Pain Medicine. 15:1911-29; 2014. Available here.

Viswanathan M, Kahwati LC, Golin CE, Blalock SJ, Coker-Schwimmer E, Posey R, Lohr KN. Medication therapy management interventions in outpatient settings: a systematic review and meta-analysis. JAMA Internal Medicine. 2015 Jan 1;175(1):76-87. Available here.

Lux LJ, Posey RE, Daniels LS, Henke DC, Durham C, Jonas DE, Lohr KN. 2014. Pharmacokinetic/Pharmacodynamic Measures for Guiding Antibiotic Treatment for Hospital-Acquired Pneumonia. Rockville (MD): Agency for Healthcare Research and Quality (US). Available here.


Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host & Microbe. 2013 Jun 12;13(6):759-72. Available here.

Dunston D, Ashby S, Krosnowski K, Ogura T, Lin W. An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization. Journal of Visualized Experiments. 2013(78). Available here.

Hawn MT, Richman JS, Vick CC, Deierhoi RJ, Graham LA, Henderson WG, Itani KM. Timing of surgical antibiotic prophylaxis and the risk of surgical site infection. JAMA Surg. 2013 Jul 1;148(7):649-57. Available here.

Jonas DE, Wilkins TM, Bangdiwala S, Bann CM, Morgan LC, Thaler KJ, Amick HR, Gartlehner G. Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration Using Real-World Trial Data and Simulation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Feb. Available here.

Lavonas EJ, Banner W, Bradt P, Bucher-Bartelson B, Brown KR, Rajan P, Murrelle L, Dart RC, Green JL. Root causes, clinical effects, and outcomes of unintentional exposures to buprenorphine by young children. Journal of Pediatrics. 163(5):1337-83. e1-3, 2013. Available here.

Watson L, Amick HR, Gaynes BN, Brownley KA, Thaker S, Viswanathan M, Jonas DE. Practice-Based Interventions Addressing Concomitant Depression and Chronic Medical Conditions in the Primary Care Setting: A Systematic Review and Meta-analysis. J Primary Care Community Health. 2013 Apr 1. Available here.

Jones WS, Schmit KM, Vemulapalli S, Subherwal S, Patel MR, Hasselblad V, Heidenfelder BL, Chobot MM, Posey R, Wing L, Sanders GD, Dolor RJ. Treatment Strategies for Patients With Peripheral Artery Disease [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 May. Available here.

McCrory DC, Coeytaux RR, Schmit KM, Kraft B, Kosinski AS, Mingo AM, Vann LM, Gilstrap DL, Hargett CW, Lugogo NL, Heidenfelder BL, Posey R, Irvine RJ, Wing L, Pendergast K, Dolor RJ. Pulmonary Arterial Hypertension: Screening, Management, and Treatment [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Apr. Available here.


Altom LK, Graham LA, Gray SH, Snyder CW, Vick CC, Hawn MT. Outcomes for incisional hernia repair in patients undergoing concomitant surgical procedures. The American Surgeon. 2012 Feb 1;78(2):243-9. Available here.

Altom LK, Deierhoi RJ, Grams J, Richman JS, Vick CC, Henderson WG, Itani KM, Hawn MT. Association between Surgical Care Improvement Program venous thromboembolism measures and postoperative events. The American Journal of Surgery. 2012 Nov 1;204(5):591-7. Available here.

Brown LE, Burton R, Hixon B, Kakade M, Bhagalia P, Vick C, Edwards A, Hawn MT. Factors influencing emergency department preference for access to healthcare. Western Journal of Emergency Medicine. 2012 Nov;13(5):410. Available here.

Campbell JP, Karolak MR, Ma Y, Perrien DS, Masood-Campbell SK, Penner NL, Munoz SA, Zijlstra A, Yang X, Sterling JA, Elefteriou F. Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol. 2012 Jul 17;10(7):e1001363. Available here.

Campbell JP, Merkel AR, Masood-Campbell SK, Elefteriou F, Sterling JA. Models of bone metastasis. Journal of visualized experiments: Journal of Visualized Experiments. 2012(67). Available here.

Cannon JA, Altom LK, Deierhoi RJ, Morris M, Richman JS, Vick CC, Itani KM, Hawn MT. Preoperative oral antibiotics reduce surgical site infection following elective colorectal resections. Diseases of the Colon & Rectum. 2012 Nov 1;55(11):1160-6. Available here.

Cheng J, Joyce A, Yates K, Aouizerat B, Sanyal AJ. Metabolomic profiling to identify predictors of response to vitamin E for non-alcoholic steatohepatitis (NASH). PLoS One. 2012 Sep 19;7(9):e44106. Available here.

Jonas DE, Garbutt JC, Brown JM, Amick HR, Brownley KA, Council CL, Viera AJ, Wilkins TM, Schwartz CJ, Richmond ER, Yeatts J, Swinson Evans T, Wood SD, Harris RP. Screening, Behavioral Counseling, and Referral in Primary Care to Reduce Alcohol Misuse. Comparative Effectiveness Review No. 64. (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I.) AHRQ Publication No. 12-EHC055-EF. Rockville, MD: Agency for Healthcare Research and Quality. July 2012. Available here.

Jonas DE, Garbutt JC, Amick HR, Brown JM, Brownley KA, Council CL, Viera AJ, Wilkins TM, Schwartz CJ, Richmond EM, Yeatts J. Behavioral counseling after screening for alcohol misuse in primary care: a systematic review and meta-analysis for the US Preventive Services Task Force. Annals of Internal Medicine. 2012 Nov 6;157(9):645-54. Available here.

Krosnowski K, Ashby S, Sathyanesan A, Luo W, Ogura T, Lin W. Diverse populations of intrinsic cholinergic interneurons in the mouse olfactory bulb. Neuroscience. 2012 Jun 28;213:161-78. Available here.

Watson LC, Amick HR, Gaynes BN, Brownley KA, Thaker S, Viswanathan M, Jonas DE. Practice-based interventions addressing concomitant depression and chronic medical conditions in the primary care setting: a systematic review and meta-analysis. Journal of Primary Care & Community Health. 2013 Oct;4(4):294-306. Available here.

Powers BJ, Crowley MJ, McCrory DC, Pendergast K, Posey R, Hadley C, Gray R, Sanders GD. Future Research Needs for Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), or Direct Renin Inhibitors (DRIs) for Treating Hypertension: Identification of Future Research Needs From Comparative Effectiveness Review No. 34 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Mar. Available here.


Altom LK, Snyder CW, Gray SH, Graham LA, Vick CC, Hawn MT. Outcomes of emergent incisional hernia repair. The American Surgeon. 2011 Aug;77(8):971-6. Available here.

Applebee MK, Joyce AR, Conrad TM, Pettigrew DW, Palsson BØ. Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli. Journal of Biological Chemistry. 2011 Jul 1;286(26):23150-9. Available here.

Graham LA, Altom LK, Vick CC, Snyder CW, Deierhoi RJ, Hawn MT. Agreement between patient survey and medical chart: Pitfalls in measurement strategies for hernia recurrence. Surgery. 2011 Sep 1;150(3):371-8. Available here.

Hawn MT, Snyder CW, Graham LA, Gray SH, Finan KR, Vick CC. Hospital-level variability in incisional hernia repair technique affects patient outcomes. Surgery. 2011 Feb 1;149(2):185-91. Available here.

Hawn MT, Gray SH, Snyder CW, Graham LA, Finan KR, Vick CC. Predictors of mesh explantation after incisional hernia repair. The American Journal of Surgery. 2011 Jul 1;202(1):28-33. Available here.

Hawn MT, Vick CC, Richman J, Holman W, Deierhoi RJ, Graham LA, Henderson WG, Itani KM. Surgical site infection prevention: time to move beyond the surgical care improvement program. Annals of Surgery. 2011 Sep 1;254(3):494-501. Available here.

Jonas DE, Wines RC, DelMonte M, Amick HR, Wilkins TM, Einerson BD, Schuler CL, Wynia BA, Shilliday BB. Drug class review: controller medications for asthma: Final update 1 report. Portland (OR): Oregon Health & Science University; 2011 Apr. Available here.

Jonas D, Van Scoyoc E, Gerrald K, Wines R, Amick H, Triplette M, Runge T. Drug class review: newer diabetes medications, TZDs, and combinations: final original report. Portland (OR): Oregon Health & Science University; 2011 Feb. Available here.

Maher BS, Vladimirov VI, Latendresse SJ, Thiselton DL, McNamee R, Kang M, Bigdeli TB, Chen X, Riley BP, Hettema JM, Chilcoat H, Murrelle EL, et al. The AVPR1A gene and substance use disorders: association, replication, and functional evidence. Biological Psychiatry. 2011 Sep 15;70(6):519-27. Available here.

Snyder CW, Graham LA, Gray SH, Vick CC, Hawn MT. Effect of mesh type and position on subsequent abdominal operations after incisional hernia repair. Journal of the American College of Surgeons. 2011 Apr 1;212(4):496-502. Available here.

Snyder CW, Graham LA, Vick CC, Gray SH, Finan KR, Hawn MT. Patient satisfaction, chronic pain, and quality of life after elective incisional hernia repair: effects of recurrence and repair technique. Hernia. 2011 Apr;15(2):123-9. Available here.

Vick CC, Graham LA, Henderson WG, Houston TK, Hawn MT. Translating preoperative smoking cessation interventions into routine clinical care of veterans: provider beliefs. Translational Behavioral Medicine. 2011 Dec 1;1(4):604-8. Available here.

Zedler BK, Joyce A, Murrelle L, Kakad P, Harpe SE. A pharmacoepidemiologic analysis of the impact of calendar packaging on adherence to self-administered medications for long-term use. Clinical Therapeutics. 2011 May 1;33(5):581-97. Available here.

Zedler BK, Kakad P, Colilla S, Murrelle L, Shah NR. Does packaging with a calendar feature improve adherence to self-administered medication for long-term use? A systematic review. Clinical Therapeutics. 2011 Jan 1;33(1):62-73. Available here.

2010 and prior

Edmiston JS, Archer KJ, Scian MJ, Joyce AR, Zedler BK, Murrelle EL. Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. Biomarkers. 15(8):715-30, 2010.

Rana GS, York TP, Edmiston JS, Zedler BK, Pounds JG, Adkins JN, Varnum SM, Smith RD, Liu Z, Li G, Webb BT, Murrelle EL, Flora JW. Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD). Anal Bioanal Chem. 397(5):1809-19, 2010.

York TP, van den Oord EJCG, Langston TB, McKinney WJ, Webb BT, Murrelle EL, Zedler BK, Edmiston JS, Flora JW: High-resolution mass spectrometry proteomics for the identification of candidate plasma protein biomarkers for chronic obstructive pulmonary disease. Biomarkers, 15(4):367-77, 2010.

Meng H, Joyce AR, Adkins DE, Basu P, Jia Y, Li G, Sengupta TK, Zedler BK, Murrelle EL, van den Oord EJCG: A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling. BMC Bioinformatics 11:227, 2010.

McClay JL, Adkins DE, Isern NG, Connell T, Wooten JB, Zedler BK, Dasika MS, Webb BT, Webb-Robertson BJ, Pounds JG, Murrelle EL, Leppert M, van den Oord EJCG: 1H Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function, J Proteome Res. 9(6):3083-90, 2010.

Conrad TM, Frazier M, Joyce AR, Cho BK, Knight EM, Lewis NE, Landick R, Palsson BØ. RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media. Proc Natl Acad Sci U S A. 107(47):20500-5, 2010.

Joyce AR, Hawkins W, Fariss MW, Sengupta TK. Role of plasma membrane disruption in reference moist smokeless tobacco-induced cell death. Toxicol Lett. 198(2):191-9, 2010.

Mitchell C, Joyce AR, Piper JT, McKallip RJ, Fariss MW. Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death. Toxicol Lett. 195(1):23-30, 2010.

Murrelle L, Coggins CR, Gennings C, Carchman RA, Carter WH Jr, Davies BD, Krauss MR, Lee PN, Schleef RR, Zedler BK, Heidbreder C: Hypotheses and fundamental study design characteristics for evaluating potential reduced-risk tobacco products. Part I: Heuristic. Regulatory Toxicology & Pharmacology 57:1-10, 2010.

Murrelle L, Gennings C, Carchman RA, Carter WH, Lee PN, Zedler BK, Coggins CRE, Heidbreder C: Further considerations on the evaluation of potential reduced-risk tobacco products. Part II: Re-assessment of a heuristic using the CPS-II database. Regulatory Toxicology & Pharmacology 57:11-17, 2010.

Hawn MT, Snyder CW, Graham LA, Gray SH, Finan KR, Vick CC. Long-term follow-up of technical outcomes for incisional hernia repair. J Am Coll Surg. 2010 May;210(5):648-55, 655-7.

Amick HR, Carpenter WR “Community-Based Participatory Research (CBPR).” In Encyclopedia of Health Services Research. Ross M Mullner, (Ed.). SAGE Publications, Inc, Thousand Oaks, CA, 2009.

Argo JL, Vick CC, Graham LA, Itani KM, Bishop MJ, Hawn MT. Elective surgical case cancellation in the Veterans Health Administration system: identifying areas for improvement. Am J Surg. Nov 2009; 198(5):600-6.

Conrad TM, Joyce AR, Applebee MK, Barrett CL, Xie B, Gao Y, Palsson BO. Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short- term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations. Genome Biol. 10(10):R118, 2009.

Mejia R, Torres de Galvis Y, Heidbreder C, Murrelle L. The Construct of Impulsivity within the Context of Gender-Specific Adversity and Resilience during Adolescence: Recommendations for Future Work. In Impulsivity: Causes, Control and Disorders, GH Lassitor (Editor), Nova Science, 2009.

Coggins CRE, Murrelle EL, Heidbreder C: Light and intermittent cigarette smokers: A review (1989-2009), Psychopharmacology (Online ISSN: 1432-2072), 2009.

Gianchandani EP, Joyce AR, Palsson BO, Papin JA. Functional States of the genome-scale Escherichia coli transcriptional regulatory system. PLoS Computational Biology, 5(6):e1000403, 2009.

Joyce AR and Palsson BO. In silico Genome-scale Metabolic Models: The Constraint-based Approach and its Applications. in Systems Biology and Synthetic Biology. P. Fu, M. Latterich and S. Panke, Eds. John Wiley & Brothers, Inc.: Hoboken, NJ; 2009. pp. 193-233.

Cherrington A, Ayala GX, Amick H, Scarinci I, Allison J, Corbie-Smith G. Applying the community health worker model to diabetes management: using mixed methods to assess implementation and effectiveness. J Health Care Poor Underserved. 2008 Nov;19(4):1044-59.

Cherrington A, Ayala GX, Amick H, Allison J, Corbie-Smith G, Scarinci I. Implementing the community health worker model within diabetes management: challenges and lessons learned from programs across the United States. Diabetes Educ. 2008 Sep-Oct;34(5):824-33.

Eaves LJ, Prom EC, Hatemi PK, Murrelle EL. Family matters: Social influences exceed genetic effects on adolescent religious attitudes and practices. Social Forces 86(4):1621-1646, 2008.

Fanous AH, Neale MC, Webb BT, Straub RE, O’Neill FA, Walsh D, Riley BP, Kendler KS. Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high density families. Biological Psychiatry 64(2):121-127, 2008.

Joyce AR and Palsson BO. Predicting gene essentiality using genome-scale in silico models. In: Osterman A and Gerdes S, editors. Gene essentiality at genome scale: protocols and bioinformatics. Totowa (NJ): Humana Press Inc.; 2008. pp. 433-457.

Meng H, Murrelle EL, Li G. Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles. BMC Bioinformatics 9:457-467, 2008.

Gray SH, Vick CC, Finan KR, Neumayer LA, Hawn MT. Umbilical Herniorrhapy in Cirrhosis: Improved Outcomes with Elective Repair. J Gastrointest Surg. Feb 13, 2008.

Hawn MT, Itani KM, Gray SH, Vick CC, Henderson W, Houston TK. Association of Timely Administration of Prophylactic Antibiotics for Major Surgical Procedures and Surgical Site Infection. J Am Coll Surg. May 2008; 206(5):814-9

Gray SH, Vick CC, Graham LA, Finan KR, Neumayer LA, Hawn MT. Variation in Mesh Placement for Ventral Hernia Repair: An Opportunity for Process Improvement?. Am J Surg. May 2008. Gray SH, Vick CC, Graham LA, Hawn MT. Enterotomy or unplanned bowel resection during elective hernia repair increases complications. Arch Surg. June 2008. 143(6) 582-6.

Weiner BJ, Amick H, Lee SY. Conceptualization and measurement of organizational readiness for change: a review of the literature in health services research and other fields. Med Care Res Rev. 2008 Aug;65(4):379-436.* “2008 Best Article of the Year” by the MCRR Editorial Board

Feist AM, Henry CS, Reed JL, Krummenacker M, Joyce AR, Karp PD, Broadbelt LJ, Hatzimanikatis V, Palsson BO. A genome-scale reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Molecular Systems Biology 3:121, 2007.

Hua Q, Joyce AR, Palsson BO, Fong SS. Metabolic characterization of Escherichia coli strains adapted to growth on lactate. Applied and Environmental Microbiology 73(14):4639-4647, 2007.

Joyce AR and Palsson BO. Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach. In: Boshoff HI and Barry CE III, editors. Systems biological approaches in infectious diseases. Basel, Switzerland: Birkhauser Verlag; 2007. pp. 265, 267-309.

Kliewer W and Murrelle L. Risk and protective factors for adolescent substance use: Findings from a study of Central American youth. Journal of Adolescent Health 40:448-455, 2007.

Van den Oord EJC, McClay J, York T, Murrelle L, Robles JR. Genetics and diagnostic refinement. Behavior Genetics 37:535-545, 2007.

Allen TE, Price ND, Joyce AR, Palsson BO. Long-range periodic patterns in microbial genomes indicate significant multi-scale chromosomal organization. PLoS Computational Biology 2(1):e2, 2006.

Gianchandani EP, Papin JA, Price ND, Joyce AR, Palsson BO. Matrix formalism to describe functional states of transcriptional regulatory systems. PLoS Comput Biol 2(8):e101 (2006).

Herring CD, Raghunathan A, Honisch C, Patel T, Applebee MK, Joyce AR, Albert TJ, Blattner FR, van den Boom D, Cantor CR, Palsson BO. Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale. Nature Genetics 38(12):1406-1412, 2006.

Hua Q, Joyce AR, Fong SS, Palsson BO. Metabolic analysis of adaptive evolution for in silico-designed lactate-producing strains. Biotechnology and Bioengineering 95(5):992-1002, 2006.

Joyce AR and Palsson BO. The model organism as a system: integrating ‘omics’ data sets. Nature Reviews Molecular Cell Biology 7(3):198-210, 2006.

Joyce AR, Easterling K, Holtzman SG, Kuhar MJ. Modeling the onset of drug dependence: a consideration of the requirement for protein synthesis. Journal of Theoretical Biology 240(4):531-537, 2006.

Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BO, Agarwalla S. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Journal of Bacteriology 188(23):8259-8271, 2006.

Kistler CE, Lewis CL, Amick HR, Bynum DL, Walter LC, Watson LC. Older adults’ beliefs about physician-estimated life expectancy: a cross-sectional survey. BMC Fam Pract. 2006 Feb 11;7:9.

Kliewer W, Murrelle L, Prom E, Ramirez M, Obando P, Sandi L, Warner E, Karenkaris M del C. Violence exposure and drug use in central american youth: family cohesion and parental monitoring as protective factors. Journal of Research on Adolescence 16:455-478, 2006.

Lewis CL, Kistler CE, Amick HR, Watson LC, Bynum DL, Walter LC, Pignone MP. Older adults’ attitudes about continuing cancer screening later in life: a pilot study interviewing residents of two continuing care communities. BMC Geriatr. 2006 Aug 3; 6(1):10.

Oh YK, Joyce AR, Palsson BO. Constraint-based genome-scale in silico models for systems biology. Asia-Pacific Biotech News 10:123-136, 2006.

Reed JL, Patel TR, Chen KH, Joyce AR, Applebee MK, Herring CD, Bui OT, Knight EM, Fong SS, Palsson BO. Systems approach to refining genome annotation. Proceedings of the National Academy of Sciences of the United States of America 103(46):17480-17484, 2006.

van den Oord EJCG, Rujescu D, Robles JR, Birrell C, Bukszár J, Murrelle L, Giegling I, Möller H-H-J, Middleton L, Muglia P. Factor structure and external validity of the PANSS revisited. Schizophrenia Research 82:213-223, 2006.

Hawn MT, Gray SH, Vick CC, Itani KM, Bishop MJ, Ordin D, Houston TK. Timely Administration of Prophylactic Antibiotics for Major Surgical Procedures. J Am Coll Surg (2006) 203:803-11.

Zhang W, Matrisian LM, Holmbeck K, Vick CC, Rosenthal EL. Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo. BMC Cancer. 2006; 6:52.

Vick CC, Finan KR, Kiefe C, Neumayer L, Hawn MT. Variation in Institutional Review processes for a multisite observational study. Am J Surg. Nov 2005; 190(5):805-809.

Finan KR, Vick CC, Kiefe CI, Neumayer L, Hawn MT. Predictors of wound infection in ventral hernia repair. Am J Surg. Nov 2005; 190(5):676-681.

Fong SS, Joyce AR, Palsson BO. Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states. Genome Research 15(10):1365-1372, 2005.

Fong SS, Joyce AR, Palsson BO. The econometrics of evolution. Nature Chemical Biology 1(4):191-192, 2005.

Silberg JL, Febo San Miguel V, Murrelle EL, Prom E, Bates J, Canino G, Egger H, Eaves LJ. Genetic and environmental influences on temperament in the first year of life: The Puerto Rico Infant Twin Study (“PRINTS”). Twin Research 8:328-336, 2005.

Davanzo P, Kerwin L, Nikore V, Esparza C, Forness S, Murrelle EL. Spanish translation and reliability testing of the child depression inventory. Child Psychiatry and Human Development 35:75-92, 2004.

Obando P, Kliewer W, Murrelle EL, Svikis DS. The comorbidity of substance abuse and depressive symptoms in Costan Rican adolescents. Drug and Alcohol Dependence 76:37-44, 2004.

Watson LC, Lewis CL, Kistler CE, ,strong>Amick HR, Boustani M. Can we trust depression screening instruments in healthy “old-old” adults? Int J Geriatr Psychiatry. 2004 Mar;19(3):278-85.

Kimmel HL and Joyce AR. Dopamine transporters: structure-activity relationships and regulation in neurons. In: Dopamine receptors and transporters, 2nd edition. Vernier P, Sidhi A, Laruelle M. editors. New York (NY): Marcel Dekker, Inc; 2003. pp. 467-500.

Kuhar MJ and Joyce AR. Is the onset of psychoactive drug effects compatible with a protein-synthesis mechanism? Neuropsychopharmacology 28 Suppl 1: S94-97, 2003.

Anderson LS, Beverly WT, Corey LA, Murrelle EL. The Mid-Atlantic Twin Registry. Twin Research 5:499-501, 2002.

Stern SJ, Arnos L, Murrelle EL, Oelrich K, Nance W, Pandya A. Attitudes of Deaf and Hard of Hearing Individuals toward Genetic Testing and Prenatal Diagnosis of Hearing Loss. Journal of Medical Genetics 39(6):449-453, 2002.

Strassberg M, Peters K, Marazita M, Ganger J, Watt-Morse M, Murrelle EL, Tarter R, Vanyukov M. Pittsburgh Registry of Infant Multiplets (PRIM). Twin Research 5:499-501, 2002.

Geisler SA, Olshan AF, Weissler MC, Cai J, Funkhouser WK, Smith J, Vick K. et al. p16 and p53 Protein expression as prognostic indicators of survival and disease recurrence from head and neck cancer. Clin Cancer Res. Nov 2002; 8(11):3445-3453.

Kimmel HL, Joyce AR, Carroll FI, Kuhar MJ. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of Pharmacology and Experimental Therapeutics 298(1): 129-140, 2001.

Kliewer W, Murrelle EL, Mejia R, Torres de Y, Angold A. Exposure to violence against a family member and internalizing symptoms in Colombian adolescents: the protective effects of family support. Journal of Consulting and Clinical Psychology 69(6):971-982, 2001.

Kuhar MJ and Joyce AR. Slow onset of CNS drugs: can changes in protein concentration account for the delay? Trends in Pharmacological Sciences 22(9):450-456, 2001.

Kuhar MJ, Joyce A, Dominguez G. Genes in drug abuse. Drug and Alcohol Dependence 62(3):157-162 2001.

Murrelle EL and McCarthy C. What’s so important about conducting research involving third parties. Journal of Continuing Education in the Health Professions 21(4):198-202, 2001.

Vrana PB, Matteson PG, Schmidt JV, Ingram RS, Joyce A, Prince KL, Dewey MJ, Tilghman SM. Genomic imprinting of a placental lactogen gene in Peromyscus. Development Genes and Evolution 211(11):523-532, 2001.

Maya J, Torres de G. Y, Murrelle EL, Mejía R, Calderón G. Consumption of psychoactive substances and other factors associated with juvenile delinquency. Monograph of the Institute for Health Sciences (CES), Medellín, Colombia, 2000.

D’Onofrio B, Eaves L, Murrelle EL, Maes H, Spilka B. Understanding biological and social influences on religious attitudes and behaviors: A behavior-genetic perspective. Journal of Personality 67:953-984, 1999.

D’Onofrio BM, Murrelle EL, Eaves LJ, McCullough ME, Landis JL, Maes HH: Adolescent religiousness and its influence on alcohol and drug use: Preliminary findings from the Mid-Atlantic Twin Study. Twin Research 60:293-305, 1999.

Maes HH, Woodard CE, Murrelle EL, Meyer JM, Silberg JL, Hewitt JK, Rutter M, Simonoff E, Pickles A, Neale MC, Eaves LJ. Tobacco, alcohol and drug use in 8-16 year old twins: The Virginia Twin Study of Adolescent Behavioral Development (VTSABD). Journal of Studies on Alcohol 60:293-305, 1999.

Pineda DA, Henao GC, Puerta IC, Mejia SE, Gomez LF, Miranda ML, Rosselli M, Ardila A, Restrepo MA, Murrelle EL. The use of brief questionnaire in the diagnosis of attention deficit. Reviews in Neurology 28(4):365-372, 1999.

Silberg JL, Pickles A, Rutter ML, Siminoff E, Hewitt JK, Maes HK, Carbonneau R, Murrelle EL, Foley D, Eaves L. The influence of genetic factors and life stress on depression among adolescent girls. Archives of General Psychiatry 56:225-232, 1999.

Breembroek GRM, van Straalen A, Witkamp GJ, van Rosmalen GM, Moss HB, Bonicatto S, Kirisci L, Giradelli AM, Murrelle EL. Substance abuse and associated psychosocial problems among argentine adolescents in Buenos Aires Province: Sex heterogeneity and familial transmission. Drug and Alcohol Dependence 52:221-230, 1998.

Majumder PP, Moss HB, Murrelle EL. Familial and non-familial factors in the prediction of disruptive behaviors in boys at risk for substance abuse. Journal of Child Psychology and Psychiatry 39:203-213, 1998.

Brigham J, Moss HB, Murrelle EL, Herning RI, Tarter RE. Event-related potential negative shift in sons of polysubstance- and alcohol-use disorder fathers. Psychiatry Research 73:133-146, 1997.

Overstreet DH, Kampov-Polevoy A, Rezvani AH, Murrelle EL, Halikas JA, Janowsky DS. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcoholism: Clinical and Experimental Research 17:1-4, 1993.

Murrelle EL, Ainsworth BE, Doody JM, Holliman SC, Bulger D. Computerized mental health screening for college students: Correlation with standard pencil and paper questionnaires. American Journal of Health Promotion 7:90-92, 1992.

Montoya ID, Murrelle EL. Prevalence of clinical depression as measured by the Zung Self-Rating Depression Scale (SDS) in physicians during post-graduate medical training in Medellín, Colombia. Medicina Universidad Pontificia Bolivariana 8(1):59-72, 1989 [Spanish].

Murrelle EL, Escalona R, Florenzano R. Epidemiologic report on psychoactive substance use in 16 countries of Latin American and the Caribbean. Bulletin of the Panamerican Health Organization 107(6):595-644, 1989.

Murrelle EL, Torres de Galvis Y, Orejuela E. Diagnostic tests as a clinical aid and for use in mental health screening. In: Application, Scoring and Interpretation Manual for the Second National Workshop on the Use of Clinical-Research Instruments in Addiction, Mental Hospital of Antioquia, Medellín, Colombia; pp. 110-115, 1988.

Murrelle EL. Alcoholism research: A new approach to an old problem. Source 2(1):23-26, 1989.

Murrelle EL. Alcoholism: Genetic and biochemical aspects. Revista del Hospital Mental de Antioquia 12(3): 13-18, 1986 [Spanish].

Murrelle EL. PC Statistician: A “friendly” biostatistics package for the microcomputer. In: Application, scoring and interpretation manual for the second national workshop on the use of clinical-research instruments in addiction. Mental Hospital of Antioquia: Medellín, Colombia; 1988. pp. 127-131.

Torres de Galvis Y, Murrelle EL. National household survey on alcoholism and the consumption of dependence-producing substances, Colombia – 1987. University of Antioquia Press: Medellín, Colombia; 1988.

Torres de Galvis Y, Murrelle EL. The consumption of dependence-producing substances in Colombia. Bulletin of the Panamerican Health Organization 107(6):485-494, 1989.